Scott Whitmore will Present his Research on March 20, 2014

Scott’s Abstract:

Insult by complement: Laying the MAC down on monkey choroidal endothelial cells

Age-related macular degeneration (AMD) is the most common cause of irreversible blindness among elderly adults in developed countries. Mounting evidence points to complement activation in the choriocapillaris as the earliest pathological change in AMD. We hypothesized that formation of the membrane attack complex (MAC), the final stage of complement activation, alters gene expression in primate choroidal endothelial cells, creating an environment conducive to AMD. To test this hypothesis, we challenged RF/6A cells with normal and heat-inactivated human serum and assessed the cellular response using immunohistochemistry and RNA-Seq. MAC treated cells showed altered gene expression in several pathways, including some implicated in AMD.


Posted on March 18, 2014, in Student Seminar. Bookmark the permalink. Leave a comment.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

%d bloggers like this: