Tara and Leah to present @ Student Seminar, Thursday 9/25

Tara Maga and Leah Olson will be presenting their current research on Sept. 25th @ noon in 2289 CBRB.  For Thursday’s talks, I have asked both Tara and Leah to supplement their talks with a small primer if anyone is interested in getting some background info related to their research.

Tara’s Talk

Title: Contributions of genes in the complement system to the pathogenesis of atypical hemolytic uremic syndrome

Abstract: Atypical hemolytic uremic syndrome (aHUS, OMIM) is characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. aHUS is far less common and more severe than typical HUS, which is caused by E. coli infection and manifests as diarrheal illness. Anecdotally aHUS is a rare disease with an estimate of a total of 300 cases reported in the USA. The pathogenesis of the disease is linked to

dysregulation of the alternative pathway of the complement cascade. Mutations in the complement regulators factor H (CFH), membrane cofactor protein (MCP), factor B (CFB), and factor I (CFI) have been

implicated in aHUS. Since only 50% of aHUS patients have mutations in known disease causing genes, we

hypothesize that there are other genes associated with aHUS. A SNP-based association study identified 13

genes involved in complement or inflammation, which we

are currently screening to determine whether they account for the other 50 percent of aHUS patients that do not have mutations in CFH, FI, or MCP.

 

Leah’s Talk

Title: The role of Irf6 in tissue regeneration.

AbstractIrf6 has recently been shown to be necessary for tissue differentiation, a process necessary for healing an epidermal injury.

Representative image of keratinocytes grown in culture

 

 

 

 

 

 

 

 

 

 

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Posted on September 23, 2008, in Student Seminar and tagged , . Bookmark the permalink. Leave a comment.

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